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BPC-157 is a penta-decapeptide composed of 15 amino acids. It is a partial sequence of the body protection compound (BPC) that was discovered in and isolated from human gastric juice.
Animal studies have shown it to accelerate the healing of many different wounds, including muscle, tendon and damaged ligaments. Additionally, BPC-157 has shown to protect organs and aids in the prevention of gastric ulcers.
BPC-157 acts systemically in the digestive tract to combat leaky gut, IBS, gastro-intestinal cramps, and Crohn’s disease. This peptide has been known to exhibit analgesic characteristics. Research has shown its ability to help skin burns heal at a faster rate by increasing blood flow to damaged tissues.
BPC-157 significantly accelerates reticulin and collagen formation as well as angiogenesis together with stimulation of macrophages and fibroblasts infiltration representing a potential therapeutic tool in wound healing management.
Benefits of Using BPC-157
BPC-157 is primarily considered a gastroprotective factor (i.e. helpful for the stomach lining), though some research also indicates potential for intestinal and even extra-intestinal healing of soft connective tissue and more.
Its varied potential mechanisms are thought to include interaction with inducible and/or endothelial nitric oxide-generating systems, by influencing serotonin, dopamine, GABA, and/or opioid metabolism, and/or by directly aiding blood flow, repair, regrowth, angiogenesis, and remodeling. Its safety profile in lab animals has been very good. Here are some of the successful rodent applications of BPC-157 to date:
Ulcerative colitis (anastomosis, short bowel syndrome and fistula)
Skeletal muscle injury
It’s important to note that very few human peer-reviewed data are currently available, and as such BPC-157 is not FDA-approved.
How to take BPC-157?
In research, BPC-157 has been successfully applied using subcutaneous, oral, topical, intra-peritoneal, intragastric, intracolonic, intrarectal, and intra-articular injectable forms.
With most peptides, oral delivery is considered problematic due to their inherent from gastric-stable peptides like BPC-157, oral delivery is typically considered problematic due to their inherent instability and inconsistent navigation through the human digestive tract. After all, breaking down proteins is just what gastric acid and protease enzymes were designed to do.
BPC-157, however, is the only peptide considered to remain stable in the acidic environment of the stomach.
There are a handful of ways to administer BPC 157 – each with a varying degree of effectiveness & ease in dosing.
Subcutaneously – BPC 157 subcutaneous injections are easy to administer at home or in the office. The needle is inserted just below the skin, into the subcutaneous fat. This is the preferred method due to convenience and efficacy.
Intramuscularly – Typically administered in-office, intramuscular injections go directly into the muscle. This is the preferred method for athletes with injuries since it is the best way to reach close to the injured area and get the fastest healing effects.
Orally – You can take BPC-157 orally in it’s liquid form if you are not a big fan of needles. This can be an effective option if you are taking BPC-157 for a GI issue. Measure your required dose with an insulin needle and squirt the liquid into the mouth and wash it down with some water or disperse the liquid from the needled into a glass of water and consume.
What Is a Peptide?
Similar in structure to proteins, peptides help maintain cellular function and regulate autoimmune responses. Our bodies naturally make more than 7,000 different peptides by combining amino acids and can absorb and utilize some peptides from foods including fermented foods, dairy, grains and fish. Perhaps unsurprisingly, breastmilk is rich in peptides.
BPC-157 is a short peptide chain, and like all peptides, it is composed of small building molecules called amino acids. Peptides, simply put, are a string of amino acids. Given that peptides send messages to cells with instructions regarding what those cells should become, they’re pretty important when it comes to the functioning of our body.
BPC stands for Body Protective Compound, and that is exactly its function. BPC-157 is most often used to treat stomach and intestinal conditions such as inflamed intestinal epithelium (leaky gut), eosinophilic esophagitis, and inflammatory bowel disease; however, its abilities to improve type 1 collagen and increase blood flow via angiogenesis means it can be a powerful peptide for wound healing and overall regeneration following injuries.
What Dosage to Use
Basic dosage: 2.5-3.75 micrograms/kilogram of body weight/time/once or twice daily.
- Measuring on an Insulin Needle: 25 syringe units/time/once or twice a day (One whole 5mg vial of BPC-157 must first be diluted with 2.5ml of bacteriostatic/sterile water).
What are the side effects of BPC-157?
Research on BPC-157 is limited, and records for its side effects are not substantial.
Considering the short half-life nature of peptides, of which BPC-157 is an example, it can initially be that the agent is generally safe. Unlike hormones that stay in the body for a long time, peptides bind to the receptor of cells, cause a chemical reaction, then go away.
However, it is better not to overlook any possible side effects. If you take BPC-157, you may get:
- Itchiness, pain, or numbness at the injection site
- Vein, muscle, or skin discomfort
- Higher blood pressure
- Increased water retention
- Unintentional weight gain/loss
Frequently Asked Questions
How does BPC-157 work?
Connective tissue healing occurs in three stages: inflammation, regeneration, and remodeling. Inflammation is when the body sends inflammatory cells to the injured site to prepare for regeneration. During regeneration, fibroblasts produce collagens and glycoproteins to form new tissues. Remodeling, the final stage, begins weeks after the injury and aims to restore maximum tissue strength. Regeneration is crucial, but the hypovascular nature of connective tissues makes it difficult to utilize the necessary building blocks from the bloodstream.
Does BPC-157 promote angiogenesis?
BPC-157 promotes angiogenesis, the formation of new blood vessels, which enhances the delivery of blood, nutrients, and oxygen to injured sites, facilitating quicker recovery.
Does BPC-157 promote production of collagen?
BPC-157 may control collagen fragments, which are smaller pieces of collagen resulting from its breakdown. Collagen fragmentation is undesirable since it compromises the structural integrity of connective tissues. While BPC-157’s role in controlling collagen is not yet proven experimentally, it is believed to promote collagen formation or defragmentation, which is crucial for recovery since connective tissues mostly consist of collagen.
Does BPC-157 promote muscle growth?
BPC-157 does not directly build muscle, but it can aid in muscle recovery, shortening the interval between rehabilitation and the next workout. Muscle tension and damage are crucial factors that lead to muscle growth. Muscle tension is challenging yet achievable weight that adapts to higher intensity. Muscle damage occurs when muscles tear at a microscopic level, and the body sends necessary materials to repair and replace them, leading to muscle growth.
How long does is take for BPC-157 to start working?
You may start seeing results after about a week, but many people experience pain relief in less than a week. The time it takes to see effects can be influenced by factors such as dosage and the severity of the injury. While some people notice immediate results, the benefits generally increase over time.